Separation of mixtures of many compounds in solution on a solid thin layer phase.
Description of organic syntheses; purity analysis of synthesis products; polymer analysis; leftover monomer content; antioxidant, plasticizer, colorant content; characterization of polymer degradation products.
Size exclusion chromatography and gel permeation chromatography
Liquid chromatographic separation of oligo- or polymer mixtures via size exclusion on microporous gels; if there are (nearly) no interactions with the stationary phase, molecules are eluted according to their hydrodynamic volume; correlation of retention time to mole mass is determined via special calibration standards or mole mass sensitive detectors.
Determination of mole mass distribution and average of soluble oligomers and polymers
Liquid chromatographic separation of compound mixtures via different interactions of the molecules in solution with the stationary phase; mobile phase and interacting groups of the stationary phase can be adjusted optimally to the properties of the substance mixture that needs to be separated.
Purity control, kinetic analysis of product spectrum in synthetic processes, method development for preparative separation procedures.
Continuous liquid chromatographic separation of complex mixtures both analytically and preparatively via timed rotation of the stationary phase; main component is a 64-port multifunctional valve, which can drive 16 columns at the same time; depending on the application, columns can be used in configurations such as simulated moving bed (SMB), continuous batch chromatography or continuous fractionation with recycling sequence; Advantages over conventional preparative technology are: higher product purities and concentrations, higher productivity, higher substance throughput with constant purity and yield, improved column use, diminished use of solvents, easier eluate work up, reproducible fractionation, automatic and continuous operation, simple transfer of a discontinuous method to continuous operation.
Fraunhofer Institute for