Biomaterials and Healthcare

The department Biomaterials and Healthcare develops biomaterials for diverse applications. Nanotechnology, surface chemistry and polymer science are combined to develop new high-tech materials for the medical engineering ready for use, such as implants and drug systems. Research and development take place in an interdisciplinary team.

• development and production of implants, in particular for ophthalmology
  
• development of bioactive surfaces for use in implants
• complex biochemical modifications
• development of polymer-bound antibody systems
  
• binding of proteins to polymer surfaces
• surface modifications/alterations
  
  
• microbiological research and development
• microbiological safety laboratory
• official approval according to § 44 IfSG
• investigations with pathogenic viruses, bacteria and fungi
  
  
• examination of genotoxicity (Ames test)
• identification of mutagens
• wound healing assay
• toxicity and drug screening with primary cell assays
  
  
• in vitro analysis
• optical microscopy (confocal laser scanning, fluorescence, etc.)
• optical spectroscopy
• biocompatibility studies
  • chemical
  • physically
  • biological
• HPLC-MS, GC-MS
  
• cytotoxicity determination
  
• in vitro studies with cell cultures
• studies on explants / expert reports
• in vitro studies with human primary cells
• in vitro studies with human tumor cells
  
• studies in vitro with viruses
• testing of pharmacological inhibitors with transfected cell lines
  

• interdisciplinary research and development in the medical field
• development of implants: intraocular lenses, artificial cornea (keratoprosthesis)
• hydrogel-based biomaterials, contact lenses
• implants with tissue-specific properties
• iInteractions between biological tissues and biomaterials
• development of methods for tailored control of cell-binding and cell-repulsive properties of biomaterials
• development of medical devices of classes I, II and III

• modern synthesis laboratories for low-and high-molecular compounds
• modern methods of molecular analysis of organic substances
• various methods of molecular weight analytics: size exclusion chromatography (GPC/SEC), cryoscopy, osmotic pressure, vapor pressure osmometry (VPO), ultracentrifuge
• polyelectrolyte titration, turbidity photometry
• UV-vis-NiR and FT-IR spectrometer
• HPLC high performance liquid chromatography coupled with MS
• thermogravimetry and differential scanning calorimetry (DSC)
• microscopes (with polarization, darkfield and phase contrast facility stereo incident light, inverse fluorescence and confocal laser scanning microscope)
• photomicrograph and digital image analysis
• dynamic light scattering
• surface tension (tensiometers, spinning drop)
• rheometer (rotation, oscillation, interfacial rheology)
• precision density measurement
• ellipsometer
• surface plasmon resonance spectrometer (SPR)
• contact angle measurement
• spin and dipcoater
• determination of the minimum film forming temperature (MFT)
• steam sterilizers, autoclaves
• ultra-high performance liquid chromatography (UHPLC) with MS coupling
• gas chromatography with MS coupling
  

• Entwicklung von Kunststoffprothesen fürs Auge (2011 | messelive.tv/german)

Hebrew University of Jerusalem | Increased bioavailability of metastatic inhibitors

Künstliche Hornhaut für Ultima-ratio-Patienten
J. Storsberg, G. I. W. Duncker, Ch. Schmidt, K. Kobuch, A. Meßner, S. Sel
Z. prakt. Augenheilkd. 34: S. 107 – 111, Potsdam, Halle, München, Sankt Augustin, Heidelberg (2013)

Nanomaterials -Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy
C. Schmidt, J. Storsberg
Biomedicines, 3/3, 203-223, pp. 2227-9059 (2015)

Artificial Cornea for ultima ratio patients
J. Storsberg, G.I.W. Duncker, C. Schmidt, K. Kobuch, A. Meßner, S.Sel
Zeitschrift für praktische Augenheilkunde, 34, pp. 107-111 (2013)

Anti-Ageing Creams, Ingedients and their Affects Against Early Skin Ageing
L. Vetter, M. W. Laughton, C. Schmidt, J. Storsberg
SOFW-Journal, 140/11, pp. 34-39 (2014)