Biomaterials and Healthcare

Quickly identifying tumors by using antibodies

Antibodies combat viruses and bacteria. They also attach themselves to cancer cells – in a typical, characteristic way. Fraunhofer scientists are using this property to detect cancer cells in tissue samples. Such rapid tests can already be applied by surgeons during operations – within a few minutes and without expensive equipment.

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Biomaterials and Healthcare

Biomaterials for medical engineering

The department Biomaterials and Healthcare develops biomaterials for diverse applications. Nanotechnology, surface chemistry and polymer science are combined to develop new high-tech materials for the medical engineering ready for use, such as implants and drug systems. Research and development take place in an interdisciplinary team.

Press releases

Our services

  • development and production of implants, in particular for ophthalmology
  • development of bioactive surfaces for use in implants
  • complex biochemical modifications
  • development of polymer-bound antibody systems
  • binding of proteins to polymer surfaces
  • surface modifications/alterations
  • in vitro analysis
  • optical microscopy (confocal laser scanning, fluorescence, etc.)
  • optical spectroscopy
  • biocompatibility studies
    • chemical
    • physically
    • biological
  • HPLC-MS, GC-MS
  • cytotoxicity determination
  • in vitro studies with cell cultures
  • studies on explants / expert reports
  • in vitro studies with human primary cells
  • in vitro studies with human tumor cells
  • studies in vitro with viruses
  • testing of pharmacological inhibitors with transfected cell lines

Our research topics

  • interdisciplinary research and development in the medical field
  • development of implants: intraocular lenses, artificial cornea (keratoprosthesis)
  • hydrogel-based biomaterials, contact lenses
  • implants with tissue-specific properties
  • iInteractions between biological tissues and biomaterials
  • development of methods for tailored control of cell-binding and cell-repulsive properties of biomaterials
  • development of medical devices of classes I, II and III

Our equipment

  • modern synthesis laboratories for low-and high-molecular compounds
  • modern methods of molecular analysis of organic substances
  • various methods of molecular weight analytics: size exclusion chromatography (GPC/SEC), cryoscopy, osmotic pressure, vapor pressure osmometry (VPO), ultracentrifuge
  • polyelectrolyte titration, turbidity photometry
  • UV-vis-NiR and FT-IR spectrometer
  • HPLC high performance liquid chromatography coupled with MS
  • thermogravimetry and differential scanning calorimetry (DSC)
  • microscopes (with polarization, darkfield and phase contrast facility stereo incident light, inverse fluorescence and confocal laser scanning microscope)
  • photomicrograph and digital image analysis
  • dynamic light scattering
  • surface tension (tensiometers, spinning drop)
  • rheometer (rotation, oscillation, interfacial rheology)
  • precision density measurement
  • ellipsometer
  • surface plasmon resonance spectrometer (SPR)
  • contact angle measurement
  • spin and dipcoater
  • determination of the minimum film forming temperature (MFT)
  • steam sterilizers, autoclaves
  • ultra-high performance liquid chromatography (UHPLC) with MS coupling
  • gas chromatography with MS coupling

Publications

Künstliche Hornhaut für Ultima-ratio-Patienten
J. Storsberg, G. I. W. Duncker, Ch. Schmidt, K. Kobuch, A. Meßner, S. Sel
Z. prakt. Augenheilkd. 34: S. 107 – 111, Potsdam, Halle, München, Sankt Augustin, Heidelberg (2013)

Nanomaterials -Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy
C. Schmidt, J. Storsberg
Biomedicines, 3/3, 203-223, pp. 2227-9059 (2015)

Artificial Cornea for ultima ratio patients
J. Storsberg, G.I.W. Duncker, C. Schmidt, K. Kobuch, A. Meßner, S.Sel
Zeitschrift für praktische Augenheilkunde, 34, pp. 107-111 (2013)

Anti-Ageing Creams, Ingedients and their Affects Against Early Skin Ageing
L. Vetter, M. W. Laughton, C. Schmidt, J. Storsberg
SOFW-Journal, 140/11, pp. 34-39 (2014)

 

 

Life Science and Bioprocesses

Functional Protein
Systems

Biomaterials and
Healthcare

Biological Building Blocks and Bioprocess Development